BDBM50251985 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine::CHEMBL480962::{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-yl}-(tetrahydro-pyran-4-yl)-amine

SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC2CCOCC2)c1

InChI Key InChIKey=PPSHLZKKNUFIFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50251985   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University Of TüBingen

Curated by ChEMBL
LigandPNGBDBM50251985(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University Of TüBingen

Curated by ChEMBL
LigandPNGBDBM50251985(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University Of TüBingen

Curated by ChEMBL
LigandPNGBDBM50251985(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University Of TüBingen

Curated by ChEMBL
LigandPNGBDBM50251985(4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5...)
Affinity DataIC50:  180nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed