BDBM50252291 CHEMBL4073879

SMILES C(COc1ccc2nc(oc2c1)-c1cccc(c1)C1=CCNCC1)CN1CCCC1

InChI Key InChIKey=PWBDDGJWWXNDJC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50252291   

TargetToll-like receptor 9(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252291(CHEMBL4073879)
Affinity DataIC50: 99nMAssay Description:Antagonist activity at human TLR9 expressed in HEK293 cells assessed as inhibition of CpGB-induced NF-kappaB activation after 24 hrs by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252291(CHEMBL4073879)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at TLR9 in human plasmacytoid dendritic cells assessed as inhibition of CpGA-induced IFN-alpha production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252291(CHEMBL4073879)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at TLR9 in human PBMC assessed as inhibition of CpGA-induced IFN-alpha production after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252291(CHEMBL4073879)
Affinity DataIC50: 8.30E+3nMAssay Description:Antagonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50252291(CHEMBL4073879)
Affinity DataIC50: 8.30E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of CL264-induced NF-kappaB activation after 24 hrs by spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed