BDBM50252729 (2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}oxime) Dihydrochloride::CHEMBL3216659::CHEMBL522503

SMILES Brc1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2\C\1=N/OCCN1CCNCC1

InChI Key InChIKey=HJVDQPRJANOXIX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50252729   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant ABL1 T315I mutant (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed