BDBM50252730 (2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}oxime) Dihydrochloride::BDBM50259591::CHEMBL3215571::CHEMBL493656

SMILES COCCN1CCN(CCO\N=C2\C(\Nc3ccccc\23)=C2\C(=O)Nc3cc(Br)ccc23)CC1

InChI Key InChIKey=HUDVRTTVWXVPMO-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50252730   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 468nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant ABL1 T315I mutant (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252730(CHEMBL3215571 | (2'Z-3'E)-6-Bromoindirubin-3'-(O-{...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed