BDBM50253745 (S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methylamino)acetamido)propanoyl)-2-oxo-3-propylpiperazin-1-yl)-N-methyl-3-(naphthalen-2-yl)propanamide::CHEMBL452710

SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC

InChI Key InChIKey=JICSVJQEGDFDBH-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50253745   

TargetMelanocortin receptor 4(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataKi:  5nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataKi:  271nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50253745((S)-2-((S)-4-((R)-3-(4-Fluorophenyl)-2-(2-(methyla...)
Affinity DataKi:  282nMAssay Description:Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed