BDBM50254401 CHEMBL4093377

SMILES FC(F)(F)c1ccc2c(Nc3ccc(Cl)nc3)n[nH]c2c1

InChI Key InChIKey=GNYBHKXPQGYGCV-UHFFFAOYSA-N

Data  6 IC50  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50254401   

TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at human TRPA1 by calcium flux based FLIPR assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
Copy BDB DOIPubMed
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TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of KCNQ1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetSodium channel protein type 5 subunit alpha(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 8.52E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to SK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetTransient receptor potential cation channel subfamily V member 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of TRPV1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50254401(CHEMBL4093377)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/10/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL