BDBM50254419 CHEMBL511391::N2-(2,6-dichlorophenyl)-N7-(4-(pyrrolidin-1-ylsulfonyl)phenyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

SMILES Clc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)ncnc2s1

InChI Key InChIKey=WMGVRVGVSGARAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50254419   

TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed