BDBM50254761 5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benzamido)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide::CHEMBL465451

SMILES Nc1c(cnn1-c1ccc(F)cc1)C(=O)NCC(O)(CN(CCO)C(=O)c1c(Cl)cccc1Cl)C(F)(F)F

InChI Key InChIKey=UXDNAIXKDXHQMU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50254761   

TargetCytochrome P450 1A2(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254761(5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254761(5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254761(5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254761(5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50254761(5-amino-N-(2-((2,6-dichloro-N-(2-hydroxyethyl)benz...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed