BDBM50254869 5-(2-chlorophenyl)-1H-indazol-3-amine::CHEMBL498859

SMILES Nc1n[nH]c2ccc(cc12)-c1ccccc1Cl

InChI Key InChIKey=XKAXPZKYFSNGLW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50254869   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  370nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  660nMAssay Description:Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  370nMAssay Description:Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human TYK2 kinase domain (885-1176 residues) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  490nMAssay Description:Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed