BDBM50255308 CHEMBL480255::N1-{(+/-)-4'-[(6''-amino-4''-methylpyridin-2''-yl)methyl)pyrrolidin-3'-yl)-N2-[4'-(trifluoromethyl)benzyl]ethane-1,2-diamine tetrahydrochloride

SMILES Cc1cc(N)nc(C[C@H]2CNC[C@H]2NCCNCc2ccc(cc2)C(F)(F)F)c1

InChI Key InChIKey=VNRFDXWZGVRTLB-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50255308   

TargetNitric oxide synthase, brain(Rat)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255308(N1-{(+/-)-4'-[(6''-amino-4''-methylpyridin-2''-yl)...)
Affinity DataKi:  197nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255308(N1-{(+/-)-4'-[(6''-amino-4''-methylpyridin-2''-yl)...)
Affinity DataKi:  1.41E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255308(N1-{(+/-)-4'-[(6''-amino-4''-methylpyridin-2''-yl)...)
Affinity DataKi:  8.40E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed