BDBM50255811 4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide::CHEMBL481806

SMILES CCOc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN(C)CC1

InChI Key InChIKey=IBHNEKVLDKCEQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50255811   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255811(4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpi...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255811(4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpi...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255811(4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpi...)
Affinity DataKi:  8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255811(4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpi...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50255811(4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpi...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed