BDBM50255902 CHEMBL4066141

SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl

InChI Key InChIKey=AEGUMSWRCVNPKS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50255902   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 10nMAssay Description:Inhibition of cytoplasmic recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 27nMAssay Description:Inhibition of cytoplasmic recombinant human His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant cytoplasmic human His-tagged KIT expressed in baculovirus using Ser/Thr 6 peptide as substrate after 1 hr by FRET-based Z'-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human His-tagged FLT3 (564 to 958 residues) expressed in baculovirus using poly (Glu,Tyr) as substrate after 2 hrs by PK-Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 40nMAssay Description:Inhibition of cytoplasmic recombinant human His-tagged FGFR3 (399 to 806 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant cytoplasmic human GST-tagged PDGFRalpha expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant human PDGFRbeta expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 167nMAssay Description:Inhibition of cytoplasmic recombinant human His-tagged FGFR4 (781 to 1338 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50255902(CHEMBL4066141)
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2019
Entry Details Article
PubMed