BDBM50256113 CHEMBL480746::N-(3,5-difluoro-4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamide

SMILES Fc1cc(NC(=O)C2COc3ccccc3C2)cc(F)c1-c1cn[nH]c1

InChI Key InChIKey=VYWFLGVPKXPOKG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50256113   

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256113(N-(3,5-difluoro-4-(1H-pyrazol-4-yl)phenyl)chroman-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256113(N-(3,5-difluoro-4-(1H-pyrazol-4-yl)phenyl)chroman-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Shanghai Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50256113(N-(3,5-difluoro-4-(1H-pyrazol-4-yl)phenyl)chroman-...)
Affinity DataIC50: 15.9nMAssay Description:Inhibition of human S6K1 using KKRNRTLTK peptide substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed