BDBM50256383 CHEMBL481545::N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-fluorochroman-3-carboxamide

SMILES CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccc(F)cc2C1)-c1cn[nH]c1

InChI Key InChIKey=DSPGFBKVTVUENE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50256383   

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed