BDBM50256745 (2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophenyl)methoxy)propanoic acid::CHEMBL475562

SMILES N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(O)=O

InChI Key InChIKey=ADUSZEGHFWRTQS-AIBWNMTMSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50256745   

TargetGalanin receptor type 2(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  21.1nMAssay Description:Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human GlyT2 expressed in porcine aorta epithelial cells assessed as reduction in [3H]-Glycine uptake at pH 7.5 by scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  100nMAssay Description:Inhibition of full length human GlyT2 expressed in FreeStyle 293-F suspension cells incubated for 30 mins before [3H]glycine addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human GlyT-1 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed