BDBM50256976 CHEMBL475820::N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)terephthalamide

SMILES Cc1ccc(NC(=O)c2ccc(cc2)C(=O)Nc2ccccc2N)cc1Nc1ncc(cn1)-c1cccnc1

InChI Key InChIKey=JUZVLELTCCUPPD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50256976   

TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256976(N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl...)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256976(N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of PDGFRbeta by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256976(N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of wild-type c-Abl by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256976(N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of VEGFR2 by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256976(N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed