BDBM50257116 CHEMBL474208::N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide

SMILES Nc1ccccc1NC(=O)c1ccc(s1)C(=O)Nc1cccc(Nc2ncc(s2)-c2cccnc2)c1

InChI Key InChIKey=AAAHTCZONLHYSA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257116   

TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257116(N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257116(N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257116(N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of wild-type c-Abl by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257116(N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of PDGFRbeta by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257116(N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed