BDBM50257177 CHEMBL2324748

SMILES CCN1CC(C1)n1nccc1-c1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=OGBDDOBYHJYBFF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50257177   

TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NaV1.4 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of human NaV1.6 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NaV1.8 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  19nMAssay Description:Inhibition of NaV1.7 ion channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  46nMAssay Description:Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human NaV1.5 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Icagen

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50:  3.14E+3nMAssay Description:Inhibition of rat NaV1.7 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed