BDBM50257209 (E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2-carboxamide::CHEMBL493315

SMILES Cc1ccc(NC(=O)c2ccc(\C=C\C(=O)NO)s2)cc1Nc1ncc(s1)-c1cccnc1

InChI Key InChIKey=XSKZXGROFJZYER-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257209   

TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of wild-type c-Abl by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of PDGFRbeta by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of VEGFR2 by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed