BDBM50257571 (R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL448971

SMILES Clc1ccccc1O[C@@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1

InChI Key InChIKey=ZKXGFMNPUCAFKG-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257571   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257571((R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50257571((R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Affinity DataKi:  3.43E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257571((R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Affinity DataEC50: >9.94E+3nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed