BDBM50257669 2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole::CHEMBL493731

SMILES CCc1nc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(C)n1CC

InChI Key InChIKey=XITZFKMHZPUYRC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257669   

TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257669(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl...)
Affinity DataIC50: 8nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257669(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50257669(2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl...)
Affinity DataIC50: 49nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed