BDBM50258121 CHEMBL495196::N-(2-chloro-4-(4-cyano-N-methylphenylsulfonamido)phenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide

SMILES CN(c1ccc(NC(=O)C(C)(O)C(F)(F)F)c(Cl)c1)S(=O)(=O)c1ccc(cc1)C#N

InChI Key InChIKey=NZPSTYAGNIOCBZ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50258121   

TargetOxysterols receptor LXR-beta(Human)
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50258121(N-(2-chloro-4-(4-cyano-N-methylphenylsulfonamido)p...)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at LXRbeta ligand binding domain by FRET based SRC1 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50258121(N-(2-chloro-4-(4-cyano-N-methylphenylsulfonamido)p...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50258121(N-(2-chloro-4-(4-cyano-N-methylphenylsulfonamido)p...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50258121(N-(2-chloro-4-(4-cyano-N-methylphenylsulfonamido)p...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at human LXRalpha expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed