BDBM50258667 (S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin::CHEMBL512101

SMILES COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(CC=C)C(=O)C(=O)c2c1

InChI Key InChIKey=NJXLWRJQLADOSG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50258667   

TargetCaspase-7(Human)
Westfalische Wilhelms-Universitat

Curated by ChEMBL
LigandPNGBDBM50258667((S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulf...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant caspase 7 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Westfalische Wilhelms-Universitat

Curated by ChEMBL
LigandPNGBDBM50258667((S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulf...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCaspase-6(Human)
Westfalische Wilhelms-Universitat

Curated by ChEMBL
LigandPNGBDBM50258667((S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulf...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human recombinant caspase 6 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCaspase-1(Human)
Westfalische Wilhelms-Universitat

Curated by ChEMBL
LigandPNGBDBM50258667((S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulf...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed