BDBM50259462 (rac)-(1RS,5SR)-7-(4-{[(2-Chloro-3,6-difluoro-benzyl)-methyl-amino]-methyl}-phenyl)-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(3-methoxy-2-methyl-benzyl)-amide::CHEMBL451603

SMILES COc1cccc(CN(C2CC2)C(=O)C2=C(CC3CNCC2N3)c2ccc(CN(C)Cc3c(F)ccc(F)c3Cl)cc2)c1C

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50259462   

TargetRenin(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259462((rac)-(1RS,5SR)-7-(4-{[(2-Chloro-3,6-difluoro-benz...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human recombinant rennin in buffer assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetRenin(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259462((rac)-(1RS,5SR)-7-(4-{[(2-Chloro-3,6-difluoro-benz...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant rennin in human plasma assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed