BDBM50259975 CHEMBL4073296

SMILES CO[C@@H]1CCN(Cc2cc(c(F)cc2F)[C@]2(C)CCSC(N)=N2)C1

InChI Key InChIKey=FSKVGYAMIKBJFU-PXAZEXFGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50259975   

TargetBeta-secretase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259975(CHEMBL4073296)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of BACE2 (unknown origin) by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259975(CHEMBL4073296)
Affinity DataIC50:  4.08E+4nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259975(CHEMBL4073296)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cathepsin D (unknown origin) by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259975(CHEMBL4073296)
Affinity DataIC50:  38nMAssay Description:Inhibition of BACE1 in human H4 cells expressing wild type APP695 assessed as reduction in soluble APPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed