BDBM50260099 CHEMBL4075567

SMILES CCS(=O)(=O)c1ccc2Oc3ccc(Cl)cc3CCCCOc3cc(=O)n(C)cc3-c2c1

InChI Key InChIKey=RTAFIPPKROYDAD-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50260099   

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260099(CHEMBL4075567)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of recombinant His-tagged BRD4 (unknown origin) using biotinylated acetyl-histone H4 as substrate by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260099(CHEMBL4075567)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal His6-tagged BRD4 BD1-BD2 (57 to 550 residues) expressed in EScherichia coli BL21(DE3) after 1 hr by Alexa-647-conjugat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260099(CHEMBL4075567)
Affinity DataEC50:  16nMAssay Description:Inhibition of BRD4 in human NCI-H1299 cells after 24 hrs by Bright-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2020
Entry Details Article
PubMed