BDBM50261071 CHEMBL4100208::US10836758, Example 40

SMILES Fc1cc(NCC2CCCO2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=XPZJAEZVONHCRC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50261071   

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261071(CHEMBL4100208 | US10836758, Example 40)
Affinity DataIC50: 189nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -60 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50261071(CHEMBL4100208 | US10836758, Example 40)
Affinity DataIC50: 261nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261071(CHEMBL4100208 | US10836758, Example 40)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -50 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261071(CHEMBL4100208 | US10836758, Example 40)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed