BDBM50261539 CHEMBL4068561

SMILES O\N=C\c1cnn2ccc(OCCCCN3CCN(CC3)c3ccc(O)c4[nH]c(=O)ccc34)cc12

InChI Key InChIKey=KHNMKPXPIOAOHB-UHFFFAOYSA-N

Data  14 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50261539   

TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  1.30nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]spiperone from human D2SR expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]spiperone from human D3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]spiperone from human D3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]spiperone from human D2LR expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]spiperone from human D2LR expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]spiperone from human D4R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]spiperone from human D4R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataEC50:  58nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cells incubated for 5 hrs by beta-Arrestin 2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cells incubated for 5 hrs by beta-Arrestin 2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2AR expressed in HEK293T cell membranes1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi: >1.50E+4nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2AR expressed in HEK293T cell membranes1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Friedrich-Alexander University Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50261539(CHEMBL4068561)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed