BDBM50262335 CHEMBL4095514

SMILES CNC(=O)c1cnc(Nc2ccc(OC)c(F)c2)cc1N[C@H]([C@H](O)CO)c1ccccc1

InChI Key InChIKey=JCKCNGWRVGOVOL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50262335   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50262335(CHEMBL4095514)
Affinity DataIC50: 13nMAssay Description:Inhibition of IRAK4 (unknown origin) using fluorescent labelled IPTSPITTTYFFFKKK peptide as substrate after 60 mins by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50262335(CHEMBL4095514)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in LTA-stimulated IL6 production pretreated for 30 mins followed by LTA stimulation after 5 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2020
Entry Details Article
PubMed