BDBM50262514 CHEMBL477587::trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitrile

SMILES FCCCOc1ccc2CN(CCc2c1)[C@H]1CC[C@@H](CC1)c1c[nH]c2ccc(cc12)C#N

InChI Key InChIKey=OIJZGDHTGREJNF-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50262514   

TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  327nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  343nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  2.31E+3nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi: >2.86E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed