BDBM50262625 CHEMBL476312::N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methanesulfonamide

SMILES CS(=O)(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1

InChI Key InChIKey=HUGQKIWTNMQGCP-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50262625   

LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataKi:  2.67E+3nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataKi: >2.70E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataKi:  4.12E+3nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed