BDBM50264158 CHEMBL488319::N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-[(4-methylpiperazin-1-yl)carbonyl]benzamide

SMILES CN1CCN(CC1)C(=O)c1ccccc1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1

InChI Key InChIKey=IABLUIXTFBYBAQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50264158   

TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264158(N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabi...)
Affinity DataIC50: 482nMAssay Description:Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264158(N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabi...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence technique in presence of NADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed