BDBM50264389 6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)phenylamino)benzo[d]isoxazole-7-carboxamide::6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide::CHEMBL491429

SMILES c1cc(cc(c1)Nc2c3ccc(c(c3on2)C(=O)Nc4cncnc4)Cl)C(F)(F)F

InChI Key InChIKey=FEGRQUWSKADGSP-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50264389   

LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 71nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 75nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 117nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 353nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed