BDBM50264804 CHEMBL4060355

SMILES OC(=O)CC1CCC2(CCN(CC2)c2ccc(cn2)-c2nc3cc(ccc3[nH]2)C(F)(F)F)OC1

InChI Key InChIKey=LFHXTDBDALXSLW-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50264804   

TargetDiacylglycerol O-acyltransferase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 33nMAssay Description:Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 34nMAssay Description:Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 34nMAssay Description:Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 800nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50264804(CHEMBL4060355)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed