BDBM50264806 CHEMBL4066339

SMILES O=C(O)C[C@@H]1COC2(CCN(c3ccc(-c4nc5cc(C(F)(F)F)ccc5[nH]4)cn3)CC2)C1

InChI Key InChIKey=GXUZUPUMLJASRP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50264806   

TargetDiacylglycerol O-acyltransferase 1(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264806BDBM50264806(CHEMBL4066339)
Affinity DataIC50: 18nMAssay Description:Inhibition of human DGAT1 expressed in yeast membrane fraction assessed as inhibition of triglyceride formation using diolein/oleoyl-CoA as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50264806BDBM50264806(CHEMBL4066339)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50264806BDBM50264806(CHEMBL4066339)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264806BDBM50264806(CHEMBL4066339)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264806BDBM50264806(CHEMBL4066339)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2020
Entry Details Article
PubMed