BDBM50264810 CHEMBL445971::N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)methanesulfonamide

SMILES CS(=O)(=O)Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=PHMPGOJWLISPFK-UHFFFAOYSA-N

Data  12 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50264810   

Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataIC50: 80nMAssay Description:Inhibition of MMP9 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  180nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  180nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  900nMAssay Description:Inhibition of MMP-14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  900nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrilysin(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  2.95E+5nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  2.95E+5nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed