BDBM50265446 3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,2-a]indol-2(1H)-yl)butyl]pyrazino[1,2-a]indol-1(2H)-one::CHEMBL495573

SMILES COc1cccc2cc3CN(CCCCN4CCn5c(cc6ccccc56)C4=O)CCn3c12

InChI Key InChIKey=GPANICKLGIVBML-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50265446   

TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  260nMAssay Description:Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  3.53E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed