BDBM50265502 CHEMBL504979::tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1[C@@H](CCC1=O)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1

InChI Key InChIKey=AFFKILKRCQTYFJ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265502   

TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265502(tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Phenylsulfonyl)-2...)
Affinity DataEC50:  90nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265502(tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Phenylsulfonyl)-2...)
Affinity DataIC50: 130nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed