BDBM50265971 CHEMBL4087393

SMILES COCCN1[C@@H](C)Cc2[nH]c(cc2C1=O)-c1nc(Nc2ccnn2C)ncc1C

InChI Key InChIKey=PNXHDOWDWLRBSB-ZDUSSCGKSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50265971   

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265971(CHEMBL4087393)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265971(CHEMBL4087393)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265971(CHEMBL4087393)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATPMore data for this Ligand-Target Pair
LigandPNGBDBM50265971(CHEMBL4087393)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265971(CHEMBL4087393)
Affinity DataIC50:  200nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair