BDBM50268183 CHEMBL4080410

SMILES COc1ccc(cc1OC)C1(SCCCS1)[C@H]1C[C@@H](O[C@@H]1CO[Si](C)(C)C(C)(C)C)n1cc(C)c(=O)[nH]c1=O

InChI Key InChIKey=XOVCHKAKMMRPCH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50268183   

TargetDNA topoisomerase 2-alpha(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Mouse)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed