BDBM50268560 CHEMBL4093128

SMILES COc1cc2CCN(CCn3cc(COc4ccccc4C(=O)Nc4ccc(cc4)C(C)(C)C)nn3)Cc2cc1OC

InChI Key InChIKey=VWVGKMQPCSSADW-UHFFFAOYSA-N

Data  13 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50268560   

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataEC50:  253nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 measured after 48 hrs b...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 5 uM measured after ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 2.5 uM measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 4.33E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 treated for 48 hrs foll...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 6.02E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 1 uM measured after ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 6.32E+3nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 treated for 48 hrs foll...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 treated for 48 hrs foll...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 0.5 uM measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 treated for 48 hrs foll...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 0.25 uM measured aft...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 3.49E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 0.1 uM measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 0.05 uM measured aft...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetATP-dependent translocase ABCB1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50268560(CHEMBL4093128)Copy SMILESCopy InChI

Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of ABCB1 in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity by measuring ADR IC50 at 0.025 uM measured af...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/5/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL