BDBM50269244 CHEMBL4076368

SMILES COc1cccc(c1)N1CCN(CC1)c1nc2CCCCc2c(=O)[nH]1

InChI Key InChIKey=SGEGLEFCEAUJJJ-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50269244   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Riken

Curated by ChEMBL

LigandBDBM50269244(CHEMBL4076368)Copy SMILESCopy InChI

Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
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TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50269244(CHEMBL4076368)Copy SMILESCopy InChI

Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
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TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Riken

Curated by ChEMBL

LigandBDBM50269244(CHEMBL4076368)Copy SMILESCopy InChI

Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
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TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL

LigandBDBM50269244(CHEMBL4076368)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human dCTPase 1More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
3/9/2020
Entry Details Article
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TargetPoly [ADP-ribose] polymerase 1(Human)
Riken

Curated by ChEMBL

LigandBDBM50269244(CHEMBL4076368)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/24/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL