BDBM50269383 CHEMBL4090562

SMILES Nc1nc(Nc2ccc(cc2)N2CCN(CC2)C2CC3CCC2C3)nn1-c1ncnc2ccc(Cl)cc12

InChI Key

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269383   

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269383(CHEMBL4090562)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269383(CHEMBL4090562)
Affinity DataEC50:  196nMAssay Description:Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269383(CHEMBL4090562)
Affinity DataEC50:  485nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed