BDBM50269387 CHEMBL4067869

SMILES Cc1csc2c(ncnc12)-n1nc(Nc2ccc(N3CCN(CC3)C3CC4CCC3C4)c(F)c2)nc1N

InChI Key

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50269387   

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269387(CHEMBL4067869)
Affinity DataEC50:  62nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269387(CHEMBL4067869)
Affinity DataEC50:  90nMAssay Description:Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed