BDBM50270630 3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl]-5-fluorobenzonitrile::CHEMBL501080

SMILES CCC1(OCC(=O)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccco1

InChI Key InChIKey=BXMUAQLRVCWTKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50270630   

TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50270630(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Affinity DataIC50: 11.8nMAssay Description:Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50270630(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50270630(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Affinity DataIC50: 690nMAssay Description:Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50270630(3-[5-Ethyl-5-(2-furyl)-2-oxo-1,2,3,5-tetrahydro-4,...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed