BDBM50271232 CHEMBL4127922

SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C)-c1cnc(N)c(OC(F)(F)F)c1)C1COC1

InChI Key InChIKey=RQVXKARCSXAEIT-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50271232   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Wuxi Apptec

Curated by ChEMBL

LigandBDBM50271232(CHEMBL4127922)Copy SMILESCopy InChI

Affinity DataKi:  67nMAssay Description:Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/23/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 12(Human)
Wuxi Apptec

Curated by ChEMBL

LigandBDBM50271232(CHEMBL4127922)Copy SMILESCopy InChI

Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/23/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL