BDBM50271964 CHEMBL4129379

SMILES C[C@@H]1CC(=O)Nc2ncnc(N3CCC(CC3)c3nc(CCC(F)(F)F)cn3CCN3CCCC3)c12

InChI Key InChIKey=QRULDXBXPXGMQS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50271964   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant AKT1 expressed in insect cells incubated for 60 mins measured at apparent ATP Km level by kinase ADP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 92nMAssay Description:Inhibition of AKT1 in human U87MG cells assessed as reduction in GSK3beta Ser9 phosphorylation incubated for 1 hr by alpha screen Surefire assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 399nMAssay Description:Inhibition of human p70S6K measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 568nMAssay Description:Inhibition of human RSK1 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human PKCbeta2 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271964(CHEMBL4129379)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of histidine-tagged human recombinant ROCK2 (11 to 552 residues) expressed in insect cells using RFARKGSLRQKNV substrate incubated for 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed