BDBM50272013 1-(4-(2-amino-3-(3-hydroxyprop-1-ynyl)pyridin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea::CHEMBL500157

SMILES Nc1nccc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)c1C#CCO

InChI Key InChIKey=HGHDKUIVPHCCKQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272013   

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50272013(1-(4-(2-amino-3-(3-hydroxyprop-1-ynyl)pyridin-4-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50272013(1-(4-(2-amino-3-(3-hydroxyprop-1-ynyl)pyridin-4-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Met kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50272013(1-(4-(2-amino-3-(3-hydroxyprop-1-ynyl)pyridin-4-yl...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed