BDBM50272188 CHEMBL4129630

SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C

InChI Key InChIKey=ISJSHQTWOHGCMM-MUUNZHRXSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272188   

TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272188(CHEMBL4129630)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272188(CHEMBL4129630)
Affinity DataIC50:  6.49E+3nMAssay Description:Inhibition of doxycycline induced Hepsin in human MCF10A cells using Boc-QRR-AMC as substrate preincubated for 24 hrs followed by doxycycline inducti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272188(CHEMBL4129630)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant Hepsin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272188(CHEMBL4129630)
Affinity DataIC50:  285nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human uPA (M1 to L431 residues) expressed in mouse NS0 cells using Z-GGR-AMC as substrate after 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed