BDBM50272704 2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methyl-5-(pentan-3-yloxy)pyrimidine::CHEMBL497653

SMILES CCC(CC)Oc1c(C)nc(nc1OC)-c1c(OC)cc(Cl)cc1OC

InChI Key InChIKey=KYWWMZUBZXRENK-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272704   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272704(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272704(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272704(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Affinity DataKi:  9nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed